This project involves the evaluation of an electronic prescribing system embedded with clinical decision support (CDS) regarding its impact on patient safety. Data is extracted from the system to investigate important safety issues such as reducing medication errors, improving infection control, ensuring the accurate electronic recording of nurse observations, and ensuring the undertaking of appropriate and timely assessments and related prescribing activities (e.g. for venous thromboembolism). The findings from the research are actively utilised and changes are subsequently made to the system as a result. A number of observational studies have also been undertaken to examine how staff interacts with the IT system and to investigate a how such a system affects communication between staff and patients. The project is funded by the National Institute for Health Research (NIHR) as part of the Collaboration for Leadership in Applied Health Research and Care (CLAHRC).